Circadian Control of Antibacterial Immunity: Findings from Animal Models

Front Cell Infect Microbiol. 2016 May 10:6:54. doi: 10.3389/fcimb.2016.00054. eCollection 2016.

Abstract

Most of the biological functions, including the immune system, are linked to circadian rhythms in living organisms. Changes occurring to biological parameters as the result of these circadian rhythms can therefore affect the outcome of a disease. For decades, model organisms have proven to be a great tool to understanding biological mechanisms such as circadian cycle and immunity. In this review, we created an inventory of the use of model organisms in order to decipher the relation between circadian rhythms and antibacterial immunity.

Keywords: antibacterial; bacteria; chrono-immunology; circadian; drosophila; mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Infections / immunology*
  • Bacterial Infections / pathology
  • CLOCK Proteins / genetics
  • CLOCK Proteins / metabolism
  • Circadian Rhythm / immunology*
  • Drosophila / immunology
  • Drosophila Proteins / metabolism
  • Humans
  • Mice
  • Models, Animal
  • Period Circadian Proteins / metabolism
  • Transcription Factor RelA / metabolism

Substances

  • Drosophila Proteins
  • PER protein, Drosophila
  • Period Circadian Proteins
  • Rela protein, mouse
  • Transcription Factor RelA
  • tim protein, Drosophila
  • CLOCK Proteins
  • Clock protein, mouse