Clonal spread of blaOXA-72-carrying Acinetobacter baumannii sequence type 512 in Taiwan

Han-Yueh Kuo; Po-Jui Hsu; Jiann-Yuan Chen; Po-Cheng Liao; Chia-Wei Lu; Chang-Hua Chen; Ming-Li Liou

doi:10.1016/j.ijantimicag.2016.04.020

Clonal spread of blaOXA-72-carrying Acinetobacter baumannii sequence type 512 in Taiwan

Int J Antimicrob Agents. 2016 Jul;48(1):111-113. doi: 10.1016/j.ijantimicag.2016.04.020. Epub 2016 May 24.

Authors

Han-Yueh Kuo¹, Po-Jui Hsu², Jiann-Yuan Chen³, Po-Cheng Liao², Chia-Wei Lu⁴, Chang-Hua Chen⁵, Ming-Li Liou⁶

Affiliations

¹ Department of Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, Taiwan; School of Medicine, National Taiwan University, Taipei City, Taiwan.
² Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsin-Chu City, Taiwan.
³ Department of Laboratory Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.
⁴ Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
⁵ Division of Infectious Diseases, Department of Internal Medicine, Changhua City, Taiwan; Center for Infectious Diseases Research, Changhua Christian Hospital, Changhua City, Taiwan; Department of Nursing, College of Medicine & Nursing, Hung Kuang University, Taichung, Taiwan. Electronic address: 76590@cch.org.tw.
⁶ Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsin-Chu City, Taiwan. Electronic address: d918229@gmail.com.

PMID: 27242318
DOI: 10.1016/j.ijantimicag.2016.04.020

Abstract

This is the first report to show an insidious outbreak of armA- and blaOXA-72-carrying Acinetobacter baumannii sequence type 512 (ST512) at a study hospital in northern Taiwan. Multilocus sequence typing revealed that this was a ST512 clone. All of the isolates with ST512 carried a novel 12,056-bp repGR2 in combination with a repGR12-type plasmid. This plasmid, designated pAB-ML, had one copy of the blaOXA-72 gene that was flanked by XerC/XerD-like sites and conferred resistance to carbapenems.

Keywords: Acinetobacter baumannii; ST512; bla(OXA-72).

MeSH terms

Acinetobacter Infections / epidemiology*
Acinetobacter Infections / microbiology
Acinetobacter baumannii / classification
Acinetobacter baumannii / enzymology*
Acinetobacter baumannii / genetics
Acinetobacter baumannii / isolation & purification
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / analysis*
Bacterial Proteins / genetics
Carbapenems / pharmacology
Disease Outbreaks*
Humans
Multilocus Sequence Typing
Plasmids / analysis*
Plasmids / classification
Taiwan / epidemiology
beta-Lactam Resistance
beta-Lactamases / analysis*
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
Bacterial Proteins
Carbapenems
OXA-72 carbapenemase, Acinetobacter baumannii
beta-Lactamases