The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction

Placenta. 2016 Jun:42:25-7. doi: 10.1016/j.placenta.2016.04.003. Epub 2016 Apr 6.

Abstract

The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygous (ANP(+/-)) and knockout (ANP(-/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(-/-) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR.

Keywords: Atrial natriuretic peptide; Fetal growth restriction; Mouse; Pre-eclampsia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atrial Natriuretic Factor / genetics*
  • Atrial Natriuretic Factor / metabolism
  • Blood Pressure / genetics*
  • Disease Models, Animal
  • Female
  • Fetal Growth Retardation / genetics*
  • Fetal Growth Retardation / metabolism
  • Fetal Growth Retardation / physiopathology
  • Mice
  • Mice, Knockout
  • Placenta / metabolism
  • Placenta / physiopathology*
  • Pre-Eclampsia / genetics*
  • Pre-Eclampsia / metabolism
  • Pre-Eclampsia / physiopathology
  • Pregnancy

Substances

  • Atrial Natriuretic Factor