Intercellular mitochondrial transfer: bioenergetic crosstalk between cells

Pratik Sinha; Mohammad N Islam; Sunita Bhattacharya; Jahar Bhattacharya

doi:10.1016/j.gde.2016.05.002

Intercellular mitochondrial transfer: bioenergetic crosstalk between cells

Curr Opin Genet Dev. 2016 Jun:38:97-101. doi: 10.1016/j.gde.2016.05.002. Epub 2016 May 25.

Authors

Pratik Sinha¹, Mohammad N Islam¹, Sunita Bhattacharya², Jahar Bhattacharya³

Affiliations

¹ Department of Medicine, Columbia University, New York, NY 10032, USA.
² Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University, New York, NY 10032, USA.
³ Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Physiology & Cellular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: jb39@columbia.edu.

Abstract

Mitochondrial transfer from donor cells to cells of injured tissues is a promising cell-based therapy for effectively bringing about recovery of tissue bioenergetics. Here, we review recent studies on intercellular mitochondrial transfer in organs and cells. We also review studies that shed light on our current understanding of the known mechanisms and conditions that lead to intercellular mitochondrial transfer.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Communication / genetics*
Energy Metabolism*
Humans
Mitochondria / genetics*
Mitochondria / metabolism

Abstract

Publication types

MeSH terms

Grants and funding