Antibodies to myelin basic protein are associated with cognitive decline after stroke

J Neuroimmunol. 2016 Jun 15:295-296:9-11. doi: 10.1016/j.jneuroim.2016.04.001. Epub 2016 Apr 9.

Abstract

B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).

Keywords: Autoimmune; Cognitive decline; MBP antibodies; Stroke.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / metabolism*
  • Cognition Disorders / etiology*
  • Cognition Disorders / immunology*
  • Cohort Studies
  • Female
  • Gene Expression Regulation / physiology
  • Humans
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Myelin Basic Protein / immunology*
  • Myelin Proteolipid Protein / immunology
  • Neuropsychological Tests
  • Stroke / complications*

Substances

  • Autoantibodies
  • Myelin Basic Protein
  • Myelin Proteolipid Protein
  • PLP1 protein, human