Hyperbilirubinemia in Preterm Neonates

Vinod K Bhutani; Ronald J Wong; David K Stevenson

doi:10.1016/j.clp.2016.01.001

Hyperbilirubinemia in Preterm Neonates

Clin Perinatol. 2016 Jun;43(2):215-32. doi: 10.1016/j.clp.2016.01.001. Epub 2016 Mar 23.

Authors

Vinod K Bhutani¹, Ronald J Wong², David K Stevenson²

Affiliations

¹ Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford Children's Health, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: bhutani@stanford.edu.
² Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford Children's Health, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA.

PMID: 27235203
DOI: 10.1016/j.clp.2016.01.001

Abstract

Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity.

Keywords: Antioxidant properties; BIND; Bilirubin; Photosensitivity; Reactive oxygen species.

Publication types

Review

MeSH terms

Gestational Age
Humans
Hyperbilirubinemia, Neonatal / complications
Hyperbilirubinemia, Neonatal / prevention & control*
Hyperbilirubinemia, Neonatal / therapy
Infant, Newborn
Infant, Premature
Kernicterus / etiology
Kernicterus / prevention & control*
Phototherapy / methods*
Risk Assessment
Time Factors