Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb

Steroids. 2016 Aug:112:95-102. doi: 10.1016/j.steroids.2016.05.007. Epub 2016 May 24.

Abstract

Seven new steroid glycosides, dioscorosides A1 (1), A2 (2), B1 (3), B2 (4), C1 (5), C2 (6), and D (7), together with 22 known ones (8-29) were isolated from the rhizomes of Dioscorea septemloba, their structures were elucidated by chemical and spectroscopic methods. All isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages. Among them, spirostane glycosides 18 and 21-24 exhibited significant inhibition of nitrite production. Moreover, the structure-activity relationship was summarized.

Keywords: Anti-inflammatory activity; Dioscorea septemloba Thunb; Steroids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Dioscorea / chemistry*
  • Macrophages / drug effects
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitrogen Oxides / metabolism
  • RAW 264.7 Cells
  • Rhizome / chemistry*
  • Steroids / chemistry*
  • Steroids / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents
  • Nitrogen Oxides
  • Steroids