HLA-A, -B, -DRB1 allele and haplotype frequencies of 920 cord blood units from Central Chile

Hum Immunol. 2016 Aug;77(8):622-623. doi: 10.1016/j.humimm.2016.05.020. Epub 2016 May 24.

Abstract

We present human leukocyte antigen (HLA) haplotype and allele/antigenic group frequencies derived from a data set of 920 umbilical cord blood units collected in Central Chile. HLA-A and -B genotypes were typed using sequence specific oligonucleotide probe methods while HLA-DRB1 genotypes were obtained from sequencing-based typing. The most frequent haplotype is A*29~B*44~DRB1*07:01 with an estimated frequency of 2.1%.

Keywords: Bioinformatics; HLA alleles; Population genetics.

MeSH terms

  • Base Sequence
  • Blood Donors
  • Blood Transfusion*
  • Chile
  • Fetal Blood
  • Gene Frequency
  • Genotype
  • HLA-A1 Antigen / genetics*
  • HLA-B Antigens / genetics*
  • HLA-DRB1 Chains / genetics*
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Genetic

Substances

  • HLA-A1 Antigen
  • HLA-B Antigens
  • HLA-DRB1 Chains