Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting

Matthias Salas; Wolfgang Drexler; Xavier Levecq; Barbara Lamory; Markus Ritter; Sonja Prager; Julia Hafner; Ursula Schmidt-Erfurth; Michael Pircher

doi:10.1364/BOE.7.001783

Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting

Biomed Opt Express. 2016 Apr 11;7(5):1783-96. doi: 10.1364/BOE.7.001783. eCollection 2016 May 1.

Authors

Matthias Salas¹, Wolfgang Drexler¹, Xavier Levecq², Barbara Lamory², Markus Ritter³, Sonja Prager³, Julia Hafner³, Ursula Schmidt-Erfurth³, Michael Pircher¹

Affiliations

¹ Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20 A-1090 Vienna, Austria.
² Imagine Eyes, 18 Rue Charles de Gaulle 91400 Orsay, France.
³ Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20 A-1090 Vienna, Austria.

Abstract

We present a new compact multi-modal imaging prototype that combines an adaptive optics (AO) fundus camera with AO-optical coherence tomography (OCT) in a single instrument. The prototype allows acquiring AO fundus images with a field of view of 4°x4° and with a frame rate of 10fps. The exposure time of a single image is 10 ms. The short exposure time results in nearly motion artifact-free high resolution images of the retina. The AO-OCT mode allows acquiring volumetric data of the retina at 200kHz A-scan rate with a transverse resolution of ~4 µm and an axial resolution of ~5 µm. OCT imaging is acquired within a field of view of 2°x2° located at the central part of the AO fundus image. Recording of OCT volume data takes 0.8 seconds. The performance of the new system is tested in healthy volunteers and patients with retinal diseases.

Keywords: (110.1080) Active or adaptive optics; (110.4500) Optical coherence tomography; (170.3890) Medical optics instrumentation; (170.4470) Ophthalmology.