In vivo Raman measurement of levofloxacin lactate in blood using a nanoparticle-coated optical fiber probe

Shupeng Liu; Ming Rong; Heng Zhang; Na Chen; Fufei Pang; Zhenyi Chen; Tingyun Wang; Jianshe Yan

doi:10.1364/BOE.7.000810

In vivo Raman measurement of levofloxacin lactate in blood using a nanoparticle-coated optical fiber probe

Biomed Opt Express. 2016 Feb 8;7(3):810-5. doi: 10.1364/BOE.7.000810. eCollection 2016 Mar 1.

Authors

Shupeng Liu¹, Ming Rong², Heng Zhang², Na Chen³, Fufei Pang², Zhenyi Chen², Tingyun Wang², Jianshe Yan⁴

Affiliations

¹ Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; liusp@shu.edu.cn.
² Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
³ Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; na.chen@shu.edu.cn.
⁴ Shanghai Institute of Immunology, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China; yanjianshe@sjtu.edu.cn.

Abstract

Monitoring drug concentrations in vivo is very useful for adjusting a drug dosage during treatment and for drug research. Specifically, cutting-edge "on-line" drug research relies on knowing how drugs are metabolized or how they interact with the blood in real-time. Thus, this study explored performing in vivo Raman measurements of the model drug levofloxacin lactate in the blood using a nanoparticle-coated optical fiber probe (optical fiber nano-probe). The results show that we were able to measure real-time changes in the blood concentration of levofloxacin lactate, suggesting that this technique could be helpful for performing drug analyses and drug monitoring in a clinical setting without repeatedly withdrawing blood from patients.

Keywords: (170.1470) Blood or tissue constituent monitoring; (170.5660) Raman spectroscopy; (290.5880) Scattering, rough surfaces.