Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays?

Abstract

Sepsis mortality rates have decreased in recent years but remain unacceptably high. Risk stratification and prognostication is of particular importance because high-risk patients may benefit from earlier clinical interventions, whereas low-risk patients may benefit from not undergoing unnecessary procedures. Prognostication is currently done mostly via clinical criteria and blood lactate levels. This article summarizes the literature on the complexity of changes at the molecular level for the casual reader.

Keywords: Biomarker; Gene expression; Microarray; Prognostics; Sepsis.