Associations between body fat distribution, insulin resistance and dyslipidaemia in black and white South African women

Cardiovasc J Afr. 2016;27(3):177-183. doi: 10.5830/CVJA-2015-088. Epub 2016 May 25.

Abstract

Aim: The aim was to examine differences in body fat distribution between premenopausal black and white South African (SA) women and explore the ethnic-specific associations with cardiometabolic risk.

Methods: Body composition, using dual-energy X-ray absorptiometry (DXA) and computerised tomography, insulin resistance (HOMA-IR) and lipid levels were assessed in 288 black and 197 white premenopausal SA women.

Results: Compared to the white women, black women had less central and more peripheral (lower-body) fat, and lower serum lipid and glucose concentrations, but similar homeostasis models for insulin resistance (HOMA-IR) values. The associations between body fat distribution and HOMA-IR, triglyceride and high-density lipoprotein cholesterol concentrations were similar, while the associations with fasting glucose, total and low-density lipoprotein cholesterol levels differed between black and white women.

Conclusion: Ethnic differences in body fat distribution are associated, in part, with differences in cardiometabolic risk between black and white SA women.

Publication types

  • Comparative Study

MeSH terms

  • Absorptiometry, Photon
  • Adiposity / ethnology*
  • Adult
  • Biomarkers / blood
  • Black People*
  • Blood Glucose / analysis
  • Cross-Sectional Studies
  • Dyslipidemias / blood
  • Dyslipidemias / diagnosis
  • Dyslipidemias / ethnology*
  • Fasting / blood
  • Female
  • Health Status Disparities*
  • Humans
  • Insulin / blood
  • Insulin Resistance / ethnology*
  • Life Style / ethnology
  • Lipids / blood
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / diagnosis
  • Metabolic Syndrome / ethnology*
  • Premenopause / ethnology
  • Risk Factors
  • South Africa / epidemiology
  • White People*
  • Young Adult

Substances

  • Biomarkers
  • Blood Glucose
  • Insulin
  • Lipids