Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

Chem Commun (Camb). 2016 Jun 18;52(48):7560-3. doi: 10.1039/c6cc03645g. Epub 2016 May 25.

Abstract

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.

MeSH terms

  • Anion Transport Proteins / metabolism*
  • Anti-Bacterial Agents / metabolism*
  • Chlorides / metabolism*
  • Liposomes
  • Methicillin-Resistant Staphylococcus aureus / growth & development
  • Methicillin-Resistant Staphylococcus aureus / metabolism*
  • Microbial Sensitivity Tests
  • Molecular Structure

Substances

  • Anion Transport Proteins
  • Anti-Bacterial Agents
  • Chlorides
  • Liposomes