Scedosporium apiospermum and S. prolificans mixed disseminated infection in a lung transplant recipient: An unusual case of long-term survival with combined systemic and local antifungal therapy in intensive care unit

Bárbara Balandin; Miriam Aguilar; Isabel Sánchez; Araceli Monzón; Isabel Rivera; Clara Salas; Miguel Valdivia; Sara Alcántara; Aris Pérez; Piedad Ussetti

doi:10.1016/j.mmcr.2016.04.006

Scedosporium apiospermum and S. prolificans mixed disseminated infection in a lung transplant recipient: An unusual case of long-term survival with combined systemic and local antifungal therapy in intensive care unit

Med Mycol Case Rep. 2016 Apr 30:11:53-6. doi: 10.1016/j.mmcr.2016.04.006. eCollection 2016 Mar.

Authors

Affiliations

¹ Intensive Care Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
² Department of Pneumology and Lung Transplant Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
³ Department of Microbiology, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
⁴ Department of Mycology, Instituto de Salud Carlos III, Majadahonda, Spain.
⁵ Department of Radiology, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
⁶ Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Spain.

Abstract

Infections due Scedosporium spp. in lung transplant recipients are associated with disseminated disease with high mortality rates. The adjunctive local antifungal therapy may be a useful option when systemic treatment is insufficient and/or surgery is not feasible. We present a case of mixed disseminated infection due Scedosporium apiospermum and S. prolificans in a lung transplant recipient. Combined local and systemic antifungal therapy provided an unusual long-term survival in the intensive care unit.

Keywords: Disseminated infection; Local antifungal therapy; Long-term survival; Lung transplant recipient; Scedosporium spp; Synergy test.