Fanconi Anemia Genes, of Menders and Sweepers

Silvia Campello; Francesco Cecconi

doi:10.1016/j.devcel.2016.05.011

Fanconi Anemia Genes, of Menders and Sweepers

Dev Cell. 2016 May 23;37(4):299-300. doi: 10.1016/j.devcel.2016.05.011.

Authors

Silvia Campello¹, Francesco Cecconi²

Affiliations

¹ Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy; IRCCS Fondazione Santa Lucia, 00143 Rome, Italy.
² Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy; IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Unit of Cell Stress and Survival, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark. Electronic address: cecconi@cancer.dk.

PMID: 27219059
DOI: 10.1016/j.devcel.2016.05.011

Abstract

Reporting recently in Cell, Sumpter et al. (2016) provide evidence that Fanconi anemia (FA) pathway genes, which are mutated in the homonymous disease and are tumor suppressors known as damaged nuclear DNA "menders," also act as intracellular sweepers in selective virophagy and mitophagy.

MeSH terms

Autophagosomes / metabolism
Autophagy / genetics
DNA Repair / genetics*
Fanconi Anemia / genetics*
Humans
Mitophagy
Models, Biological