Solubilization and characterization of a ouabain-sensitive protein from transverse tubule membrane-junctional sarcoplasmic reticulum complexes (TTM-JSR) in cat cardiac muscle

Experientia. 1989 May 15;45(5):466-9. doi: 10.1007/BF01952032.

Abstract

A new glycoprotein of 31,500 dalton, which has a high affinity for ouabain, and is independent of (Na+-K+)-ATPase, was solubilized from transverse tubule membrane and junctional sarcoplasmic reticulum complexes (TTM-JSR) of cat cardiac muscle. This protein could be extracted only in small amounts from sarcolemma-plasma membrane (SLM-PL) fragments, suggesting that it indeed originates from the TTM-JSR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats
  • Cell Membrane / metabolism*
  • Cell Membrane / ultrastructure
  • Heart Ventricles / metabolism
  • Membrane Glycoproteins / isolation & purification
  • Membrane Glycoproteins / metabolism*
  • Microtubules / metabolism*
  • Microtubules / ultrastructure
  • Molecular Weight
  • Myocardium / metabolism*
  • Myocardium / ultrastructure
  • Ouabain / pharmacology*
  • Sarcoplasmic Reticulum / metabolism*
  • Sarcoplasmic Reticulum / ultrastructure
  • Solubility

Substances

  • Membrane Glycoproteins
  • Ouabain