GPR55: Metabolic Help or Hindrance?

Trends Endocrinol Metab. 2016 Sep;27(9):606-608. doi: 10.1016/j.tem.2016.04.012. Epub 2016 May 21.

Abstract

Since the discovery of the lysophospholipid-sensitive receptor GPR55, hopes have been raised that targeting this G protein-coupled receptor (GPCR) may represent a novel approach for the treatment of metabolic disorders. We discuss conflicting evidence surrounding GPR55 physiology and highlight its potential as a novel target for the treatment of obesity and diabetes.

Keywords: GPR55; LPI; diabetes; metabolism; obesity.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Metabolic Diseases / genetics
  • Metabolic Diseases / metabolism*
  • Obesity / genetics
  • Obesity / metabolism
  • Receptors, Cannabinoid
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • GPR55 protein, human
  • Receptors, Cannabinoid
  • Receptors, G-Protein-Coupled