The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

Abstract

Signal transduction and kinomics have been rapidly expanding areas of investigation within the malaria research field. Here, we provide an overview of phosphosignalling pathways that operate in all stages of the Plasmodium life cycle. We review signalling pathways in the parasite itself, in the cells it invades, and in other cells of the vertebrate host with which it interacts. We also discuss the potential of these pathways as novel targets for antimalarial intervention.

Keywords: Malaria; Phosphorylation; Plasmodium; Protein kinase; Protein phosphatase; Signalling.