[Potentially toxic antibiotics concentrations after administration using impregnated dressing in a severe burned patient: A case report]

Abstract

Severe burned patients present high risk of skins infections, frequently due to Pseudomonas aeruginosa. Impregnated dressings with amikacin or colistin could be a good alternative to obtain effective concentration directly at the infected site. Therapeutic drug monitoring for these antibiotics is currently recommended after an intravenous administration to obtain effective and non-toxic plasmatic concentrations. However, data are lacking about systemic exposition and risk of toxicity after an administration with impregnated dressings. We report the case of a severe burned patient with cutaneous infection treated with amikacin and colistin impregnated dressings, for which plasmatic pharmacokinetic profiles were performed.

Keywords: Aminoglycosid; Aminoglycosides; Brûlure; Burns; Colimycine; Colistin; Cutaneus infection; Infection cutanée; Suivi thérapeutique pharmacologique; Therapeutic drug monitoring.