Abstract
We developed a novel approach to assess tumor vascularity using recombinant Gaussia luciferase (rGluc) protein and bioluminescence imaging. Upon intravenous injection of rGluc followed by its substrate coelenterazine, non-invasive visualization of tumor vascularity by bioluminescence imaging was possible. We applied this method for longitudinal monitoring of tumor vascularity in response to the anti-angiogenic drug tivozanib. This simple and sensitive method could be extended to image blood vessels/vasculature in many different fields.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Angiogenesis Inhibitors / administration & dosage*
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Animals
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Cell Line, Tumor
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Copepoda / enzymology
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Humans
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Imidazoles / administration & dosage*
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Luciferases / metabolism*
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Luminescent Agents / administration & dosage*
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Luminescent Measurements
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Neoplasm Transplantation
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Neoplasms / blood supply*
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Neoplasms / drug therapy
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Neoplasms / metabolism
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Neoplasms / pathology
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Phenylurea Compounds / administration & dosage*
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Pyrazines / administration & dosage*
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Quinolines / administration & dosage*
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Recombinant Proteins / administration & dosage
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Treatment Outcome
Substances
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Angiogenesis Inhibitors
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Imidazoles
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Luminescent Agents
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Phenylurea Compounds
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Pyrazines
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Quinolines
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Recombinant Proteins
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tivozanib
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coelenterazine
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Luciferases