Ibrutinib is a safe and effective therapy for systemic mantle cell lymphoma with central nervous system involvement - a multi-centre case series from the United Kingdom

Br J Haematol. 2017 Jul;178(2):327-329. doi: 10.1111/bjh.14122. Epub 2016 May 16.

Authors

David L Tucker¹, Georgina Naylor², Anton Kruger², Malcolm S Hamilton³, George Follows⁴, Simon A Rule¹

Affiliations

¹ Department of Haematology, Plymouth Hospitals NHS Trust, Plymouth, Devon, UK.
² Department of Haematology, Royal Cornwall Hospital, Truro, UK.
³ Department of Haematology, Royal Devon and Exeter Hospital, Exeter, UK.
⁴ Addenbrooke's Hospital, Cambridge, UK.

PMID: 27197509
DOI: 10.1111/bjh.14122

No abstract available

Keywords: central nervous system; ibrutinib; lymphoma.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives
Aged
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / adverse effects
Antineoplastic Agents / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain / pathology
Central Nervous System Neoplasms / diagnosis
Central Nervous System Neoplasms / drug therapy*
Central Nervous System Neoplasms / secondary*
Humans
Lymphoma, Mantle-Cell / drug therapy*
Lymphoma, Mantle-Cell / pathology*
Magnetic Resonance Imaging / methods
Male
Middle Aged
Multicenter Studies as Topic
Piperidines
Protein Kinase Inhibitors / administration & dosage
Protein Kinase Inhibitors / adverse effects
Protein Kinase Inhibitors / therapeutic use*
Pyrazoles / administration & dosage
Pyrazoles / adverse effects
Pyrazoles / therapeutic use*
Pyrimidines / administration & dosage
Pyrimidines / adverse effects
Pyrimidines / therapeutic use*
Recurrence
Retreatment
Treatment Outcome
United Kingdom

Substances

Antineoplastic Agents
Piperidines
Protein Kinase Inhibitors
Pyrazoles
Pyrimidines
ibrutinib
Adenine