"Greening" a chemical transformation is not about only changing the nature of a solvent or decreasing the reaction temperature. There are metrics enabling a critical quantification of the efficiency of an experimental protocol. Some of them are applied to different sequences for the preparation of paracetamol in order to understand their performance parameters and elucidate pathways for improvement.
Keywords: E factor; atom economy; ecoscale; green chemistry; life cycle analysis; paracetamol; reaction mass efficiency; stoichiometric factor; waste; yield.