Bioresorbable vascular scaffolds (BRS) are novel devices designed to provide transient vessel support to drug-delivery capability without the potential long-term limitations of metallic drug-eluting stents. The technology, heralded as the latest revolution in the field of percutaneous coronary intervention, could overcome many of the long-term safety concerns associated with metallic stents and possibly even convey a further clinical benefit. However, despite its theoretical advantages, the safety and efficacy of the first generation BRS remain unclear in all-comer patient populations. Invasive imaging modalities and methodologies were developed to guide BRS implantation and monitor the interaction between the scaffold and the vessel at long-term follow-up. These tools are helpful to avoid some of the pitfalls associated with BRS implantation and may improve the clinical outcome of these devices. The present review aims to report the most recent data regarding multi-imaging modalities as guidance and follow-up of coronary interventions involving the use of BRS.