Abstract
The effect of acute hypoxia on the occurrence of apoptosis in eye cells in rats placed in a pressure chamber was studied. Selective primary lesion of cells of the conjunctiva and the anterior corneal epithelium was found. A possible role of the simulated hypoxic conditions in the dry eye syndrome pathogenesis, which is accompanied by primary lesion of cells in the anterior eye surface tissues is discussed.
MeSH terms
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Animals
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Apoptosis / physiology*
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Benzimidazoles
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Conjunctiva / pathology
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Conjunctiva / physiopathology*
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Cornea / pathology
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Cornea / physiopathology*
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DNA Damage / physiology
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Disease Models, Animal
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Dry Eye Syndromes
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Fluorescent Dyes
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Hypoxia / pathology
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Hypoxia / physiopathology*
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In Situ Nick-End Labeling
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Male
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Microscopy, Fluorescence
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Pressure
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Rats, Wistar
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Seizures / pathology
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Seizures / physiopathology
Substances
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Benzimidazoles
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Fluorescent Dyes
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bisbenzimide ethoxide trihydrochloride