FAAH inhibitors in the limelight, but regrettably

Int J Clin Pharmacol Ther. 2016 Jul;54(7):498-501. doi: 10.5414/CP202687.

Abstract

This short review focuses on the recent drug development of FAAH inhibitors, as recent serious adverse events have been reported in a phase I study with a compound of this class. The authors overview the potential interest in targeting FAAH inhibition, the current programs, and the available information on the recent dramatic events.

Publication types

  • Editorial
  • Review

MeSH terms

  • Amidohydrolases / antagonists & inhibitors*
  • Amidohydrolases / metabolism
  • Brain / drug effects*
  • Brain / physiopathology
  • Brain Death
  • Brain Diseases / chemically induced*
  • Brain Diseases / mortality
  • Brain Diseases / physiopathology
  • Clinical Trials, Phase I as Topic
  • Coma / chemically induced
  • Coma / mortality
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Early Termination of Clinical Trials
  • Enzyme Inhibitors / adverse effects*
  • Humans
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome

Substances

  • Enzyme Inhibitors
  • Amidohydrolases
  • fatty-acid amide hydrolase