Abstract
We report three cases of patients with developmental-delay from neonatal herpetic encephalitis and/or meningitis who presented years later with acute retinal necrosis due to herpes simplex virus. The diagnosis was delayed in all cases due to the patients' inability to verbalize their ocular complaints and cooperate with eye examinations. This case series documents the clinical course, pathophysiologic mechanism, and treatment of acute retinal necrosis in this patient population. Clinicians should understand the importance of prudent consideration of acute retinal necrosis in patients with a history of neonatal herpetic encephalitis and/or meningitis presenting with a red eye.
Keywords:
ARN; encephalitis; herpes; retinitis; uveitis.
MeSH terms
-
Acyclovir / therapeutic use
-
Adult
-
Antibodies, Viral / blood
-
Antiviral Agents / therapeutic use
-
Child
-
DNA, Viral / genetics
-
Developmental Disabilities / diagnosis*
-
Developmental Disabilities / drug therapy
-
Developmental Disabilities / virology
-
Drug Combinations
-
Encephalitis, Herpes Simplex / diagnosis*
-
Encephalitis, Herpes Simplex / drug therapy
-
Encephalitis, Herpes Simplex / virology
-
Eye Infections, Viral / diagnosis*
-
Eye Infections, Viral / drug therapy
-
Eye Infections, Viral / virology
-
Glucocorticoids / therapeutic use
-
Humans
-
Infant, Newborn
-
Infant, Newborn, Diseases / diagnosis*
-
Infant, Newborn, Diseases / virology
-
Male
-
Polymerase Chain Reaction
-
Retinal Necrosis Syndrome, Acute / diagnosis*
-
Retinal Necrosis Syndrome, Acute / drug therapy
-
Retinal Necrosis Syndrome, Acute / virology
-
Simplexvirus / physiology
-
Virus Activation
-
Vitreous Body / virology
Substances
-
Antibodies, Viral
-
Antiviral Agents
-
DNA, Viral
-
Drug Combinations
-
Glucocorticoids
-
Acyclovir