Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208

MeSH terms

• Biphenyl Compounds / therapeutic use*
• Cell Line, Tumor
• Drug Resistance, Neoplasm / genetics
• ELAV-Like Protein 1 / genetics*
• Gene Expression Regulation, Leukemic / drug effects
• High-Throughput Nucleotide Sequencing
• Humans
• Leukemia, Myeloid, Acute / drug therapy*
• Leukemia, Myeloid, Acute / genetics*
• Leukemia, Myeloid, Acute / pathology
• Oncogene Proteins, Fusion / genetics*
• Protein Kinase Inhibitors / therapeutic use
• TYK2 Kinase / genetics*
• Thiazolidines / therapeutic use*