1 Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium; Department of Intensive Care Medicine, University Hospital Bern (Inselspital), Bern, Switzerland; Unidade de Cuidados Intensivos Neurocríticos, Hospital de São José, Centro Hospitalarde Lisboa Central, Lisbon, Portugal; Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany; Department of Intensive Care, St. Michael's Hospital, Toronto, ON, Canada.