Changes in Corneal Thickness and Specular Microscopic Indices in Acute Unilateral Anterior Uveitis

Ocul Immunol Inflamm. 2016 Jun;24(3):288-92. doi: 10.3109/09273948.2014.970279. Epub 2016 May 16.

Abstract

Purpose: To compare central corneal thickness (CCT) and specular microscopic indices in active unilateral anterior uveitis with the same indices 1 week after the initiation of treatment.

Methods: This study included 30 eyes with active unilateral idiopathic anterior uveitis. CCT and specular microscopic indices were compared before and after 1 week of the treatment with topical medications.

Results: At the first visit, mean CCT was significantly greater in affected eyes (mean ± standard deviation: 514.0 ± 23.0) than in fellow eyes (493.2 ± 10.6) (p < 05). There was a significant decrease in CCT of the involved eye 1 week after start of treatment to 494.1 ± 23.1 μm (p < 05). No significant differences were observed in the specular microscopic indices between the affected and fellow eyes before treatment and 1 week after the treatment.

Conclusion: We found that eyes with unilateral active anterior uveitis had increased CCT in comparison to their healthy fellow eyes without a change in the specular microscopic indices.

Keywords: Anterior uveitis; central corneal thickness; specular microscopy.

MeSH terms

  • Acute Disease
  • Adult
  • Betamethasone / therapeutic use
  • Cornea / pathology*
  • Corneal Diseases / diagnosis
  • Corneal Diseases / drug therapy
  • Corneal Diseases / etiology*
  • Drug Combinations
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Male
  • Microscopy
  • Middle Aged
  • Ophthalmic Solutions
  • Organ Size
  • Parasympatholytics / therapeutic use
  • Tropanes / therapeutic use
  • Uveitis, Anterior / complications*
  • Uveitis, Anterior / diagnosis
  • Uveitis, Anterior / drug therapy
  • Young Adult

Substances

  • Drug Combinations
  • Glucocorticoids
  • Ophthalmic Solutions
  • Parasympatholytics
  • Tropanes
  • homatropine
  • Betamethasone