Unlocking the code: mining the urinary proteome after renal transplantation

Zoltan H Endre; Mangalee Fernando

doi:10.1016/j.kint.2016.03.008

Unlocking the code: mining the urinary proteome after renal transplantation

Kidney Int. 2016 Jun;89(6):1183-5. doi: 10.1016/j.kint.2016.03.008.

Authors

Zoltan H Endre¹, Mangalee Fernando²

Affiliations

¹ Department of Nephrology, Prince of Wales Hospital and Clinical School, University of New South Wales, Sydney, Australia. Electronic address: z.endre@unsw.edu.au.
² Department of Nephrology, Prince of Wales Hospital and Clinical School, University of New South Wales, Sydney, Australia.

PMID: 27181772
DOI: 10.1016/j.kint.2016.03.008

Abstract

Diagnosis of transplant dysfunction usually requires kidney biopsy. Sidgel et al. compared urinary proteomics with matched kidney biopsies to develop a biomarker panel to differentiate acute rejection, BK viral nephropathy, and chronic allograft nephropathy. The results suggest that monitoring a panel of urinary peptides may ultimately facilitate noninvasive diagnosis and management of common transplant complications.

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MeSH terms

BK Virus*
Graft Rejection
Humans
Kidney
Kidney Transplantation*
Proteome
Urinary Tract

Substances

Proteome