Emergence of an NDM-5-producing clinical Escherichia coli isolate in Egypt

Ahmed M Soliman; Hazim O Khalifa; Ashraf M Ahmed; Toshi Shimamoto; Tadashi Shimamoto

doi:10.1016/j.ijid.2016.05.003

Emergence of an NDM-5-producing clinical Escherichia coli isolate in Egypt

Int J Infect Dis. 2016 Jul:48:46-8. doi: 10.1016/j.ijid.2016.05.003. Epub 2016 May 9.

Authors

Ahmed M Soliman¹, Hazim O Khalifa², Ashraf M Ahmed³, Toshi Shimamoto⁴, Tadashi Shimamoto⁵

Affiliations

¹ Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan; Department of Microbiology and Immunology, Faculty of Pharmacy and Drug Industries, Kafrelsheikh University, Kafr El-Sheikh, Egypt.
² Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan; Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt.
³ Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan; Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt.
⁴ Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan.
⁵ Laboratory of Food Microbiology and Hygiene, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan. Electronic address: tadashis@hiroshima-u.ac.jp.

PMID: 27173077
DOI: 10.1016/j.ijid.2016.05.003

Abstract

The first occurrence of New Delhi metallo-β-lactamase 5 (NDM-5), carried on an IncI1-Iγ-type plasmid of >93kb in a multidrug-resistant Escherichia coli strain in Kafr El-Sheikh, Egypt, is reported. The strain was isolated from a wound pus swab from a patient diagnosed with a fracture of the right femur. This E. coli strain was found to belong to sequence type (ST) 5018 and also to carry other resistance genes, including blaCTX-M-15, blaCMY-42, blaOXA-1, and aac(6')-Ib-cr.

Keywords: Carbapenem-resistant; Egypt; Escherichia coli; NDM-5; New Delhi metallo-β-lactamase 5; Sequence type.

Publication types

Case Reports

MeSH terms

Aged
Anti-Bacterial Agents / administration & dosage
Egypt
Escherichia coli / classification
Escherichia coli / enzymology
Escherichia coli / genetics
Escherichia coli / isolation & purification*
Escherichia coli Infections / drug therapy
Escherichia coli Infections / microbiology*
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism*
Humans
Male
Plasmids / genetics
Plasmids / metabolism
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Escherichia coli Proteins
beta-Lactamases