NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells

Chem Commun (Camb). 2016 Jun 28;52(51):7939-42. doi: 10.1039/c6cc02571d. Epub 2016 May 12.

Abstract

In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed and applied for efficient production of (1)O2 by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O2 generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm / drug effects
  • Humans
  • Hydrogen Peroxide / chemistry*
  • Hypoxia / metabolism
  • Hypoxia / pathology
  • Hypoxia / therapy*
  • Infrared Rays*
  • Male
  • Nanocomposites / chemistry*
  • Photochemical Processes
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Phototherapy*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy*
  • Structure-Activity Relationship

Substances

  • Photosensitizing Agents
  • Hydrogen Peroxide