Abstract
In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed and applied for efficient production of (1)O2 by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O2 generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Resistance, Neoplasm / drug effects
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Humans
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Hydrogen Peroxide / chemistry*
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Hypoxia / metabolism
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Hypoxia / pathology
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Hypoxia / therapy*
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Infrared Rays*
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Male
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Nanocomposites / chemistry*
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Photochemical Processes
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Phototherapy*
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / pathology
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Prostatic Neoplasms / therapy*
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Structure-Activity Relationship
Substances
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Photosensitizing Agents
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Hydrogen Peroxide