Lignan Glucosides from the Stem Barks of Illicium difengpi

Molecules. 2016 May 10;21(5):607. doi: 10.3390/molecules21050607.

Abstract

In this study, four new lignan glucosides, named difengpiosides A-D (1-4), were isolated from the stem barks of Illicium difengpi, together with seven known compounds 5-11. Their structures were identified on the basis of spectroscopic analyses (1D and 2D NMR, HRESIMS, CD) and a comparison with literature data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.

Keywords: Illicium difengpi; NO inhibition; difengpiosides A–D; lignan glucosides; stem barks.

MeSH terms

  • Animals
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Illicium / chemistry*
  • Lignans / analysis*
  • Lipopolysaccharides / pharmacology
  • Mice
  • Molecular Structure
  • Nitric Oxide / analysis*
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plant Stems / chemistry
  • RAW 264.7 Cells

Substances

  • Glucosides
  • Lignans
  • Lipopolysaccharides
  • Plant Extracts
  • Nitric Oxide