Autoimmune hepatitis following drug-induced liver injury in an elderly patient

Clin J Gastroenterol. 2016 Jun;9(3):156-9. doi: 10.1007/s12328-016-0648-5. Epub 2016 May 12.

Abstract

We describe a case of autoimmune hepatitis (AIH) that may have occurred following drug-induced liver injury with camostat mesilate and/or benzbromarone in an elderly patient. The patient's liver biopsy showed chronic active hepatitis and autoimmune hepatitis. Stopping the use of these drugs did not lead to complete remission, but the use of a low dose of corticosteroids completely cured his liver dysfunction. In the present case, liver dysfunction was caused by an autoimmune mechanism. Special attention should be paid to idiopathic AIH and drug-induced AIH in elderly patients.

Keywords: Autoimmune hepatitis; Benzarone; Benzbromarone; Camostat mesilate.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Benzbromarone / adverse effects
  • Biopsy
  • Chemical and Drug Induced Liver Injury / complications*
  • Chemical and Drug Induced Liver Injury / pathology
  • Esters
  • Gabexate / adverse effects
  • Gabexate / analogs & derivatives
  • Guanidines
  • Hepatitis, Autoimmune / etiology*
  • Hepatitis, Autoimmune / pathology
  • Hepatitis, Chronic / etiology
  • Hepatitis, Chronic / pathology
  • Humans
  • Liver / pathology
  • Male
  • Uricosuric Agents / adverse effects

Substances

  • Esters
  • Guanidines
  • Uricosuric Agents
  • camostat
  • Benzbromarone
  • Gabexate