Abstract
Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.
MeSH terms
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Biomarkers, Tumor / analysis*
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Endoplasmic Reticulum / chemistry
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Endoplasmic Reticulum / drug effects*
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Endoplasmic Reticulum / metabolism
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Fluorescence*
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Fluorescent Dyes / chemistry*
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HeLa Cells
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Humans
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Molecular Structure
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Structure-Activity Relationship
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Tunicamycin / chemistry
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Tunicamycin / pharmacology*
Substances
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Biomarkers, Tumor
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Fluorescent Dyes
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Tunicamycin