Disulfiram inhibits chocolate self-administration and reinstatement to chocolate seeking in rats

Alessandro Zaru; Paola Maccioni; Giancarlo Colombo; Gian Luigi Gessa

doi:10.1016/j.pbb.2016.04.008

Disulfiram inhibits chocolate self-administration and reinstatement to chocolate seeking in rats

Pharmacol Biochem Behav. 2016 Sep:148:119-27. doi: 10.1016/j.pbb.2016.04.008. Epub 2016 May 8.

Authors

Alessandro Zaru¹, Paola Maccioni², Giancarlo Colombo³, Gian Luigi Gessa¹

Affiliations

¹ Neuroscience Institute, National Research Council of Italy, Section of Cagliari, S.S. 554, km. 4500, I-09042 Monserrato, CA, Italy; Department of Biomedical Sciences, University of Cagliari, S.S. 554, km. 4500, I-09042 Monserrato, CA, Italy.
² Neuroscience Institute, National Research Council of Italy, Section of Cagliari, S.S. 554, km. 4500, I-09042 Monserrato, CA, Italy.
³ Neuroscience Institute, National Research Council of Italy, Section of Cagliari, S.S. 554, km. 4500, I-09042 Monserrato, CA, Italy. Electronic address: colomb@unica.it.

PMID: 27169812
DOI: 10.1016/j.pbb.2016.04.008

No abstract available

Keywords: Chocolate; Disulfiram; Inhibition of aldehyde dehydrogenase (ALDH); Inhibition of dopamine β-hydroxylase (DBH); Operant self-administration; Rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohol Deterrents / pharmacology
Alcohol Deterrents / therapeutic use
Animals
Behavior, Addictive / drug therapy
Behavior, Addictive / psychology
Chocolate*
Disulfiram / pharmacology*
Disulfiram / therapeutic use
Dose-Response Relationship, Drug
Male
Motivation / drug effects*
Motivation / physiology
Rats
Rats, Wistar
Reaction Time / drug effects*
Reaction Time / physiology
Reinforcement Schedule*
Self Administration

Substances

Alcohol Deterrents
Disulfiram