Lung Cancer Resets the Liver's Metabolic Clock

Rob A Cairns; Tak W Mak

doi:10.1016/j.cmet.2016.04.028

Lung Cancer Resets the Liver's Metabolic Clock

Cell Metab. 2016 May 10;23(5):767-9. doi: 10.1016/j.cmet.2016.04.028.

Authors

Rob A Cairns¹, Tak W Mak²

Affiliations

¹ The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C1, Canada.
² The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C1, Canada. Electronic address: tmak@uhnresearch.ca.

PMID: 27166941
DOI: 10.1016/j.cmet.2016.04.028

Abstract

The impact of a tumor on distant organs is not well characterized but may be important for understanding immune interactions and the process of metastasis. Masri and colleagues (2016) now identify an interesting effect of lung tumor development on circadian regulation of liver metabolism.

MeSH terms

Adenocarcinoma / metabolism
Adenocarcinoma / pathology
Adenocarcinoma of Lung
Animals
Circadian Clocks*
Humans
Liver / metabolism*
Lung Neoplasms / metabolism*
Lung Neoplasms / pathology
Models, Biological
Mutation / genetics
Signal Transduction