Immunology: You Remind Me of a Microbe I Know

Curr Biol. 2016 May 9;26(9):R373-6. doi: 10.1016/j.cub.2016.03.064.

Abstract

The majority of bacteria found within the gut are commensals, although it is unclear whether these organisms can elicit systemic immunity. New research indicates that gut-microbiota-specific serum antibodies targeting an epitope conserved among Gram-negative bacteria can protect the host from systemic pathogenic infection.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology*
  • Antibody Specificity
  • Bacterial Infections / immunology
  • Epitopes
  • Gastrointestinal Microbiome / immunology*
  • Gastrointestinal Microbiome / physiology*
  • Gram-Negative Bacteria / classification*
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / immunology*
  • Mice
  • Mice, Knockout
  • Toll-Like Receptors

Substances

  • Antibodies, Bacterial
  • Epitopes
  • Toll-Like Receptors