Long Non-coding RNAs in the Cytoplasm

Farooq Rashid; Abdullah Shah; Ge Shan

doi:10.1016/j.gpb.2016.03.005

Long Non-coding RNAs in the Cytoplasm

Genomics Proteomics Bioinformatics. 2016 Apr;14(2):73-80. doi: 10.1016/j.gpb.2016.03.005. Epub 2016 May 6.

Authors

Farooq Rashid¹, Abdullah Shah¹, Ge Shan²

Affiliations

¹ CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
² CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address: shange@ustc.edu.cn.

Abstract

An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability, regulating mRNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.

Keywords: MicroRNA; ceRNA; lncRNA; mRNA stability; mRNA translation.

Publication types

Review

MeSH terms

Animals
Cytoplasm / metabolism*
Humans
MicroRNAs / genetics
MicroRNAs / metabolism
Phosphorylation
Protein Biosynthesis / genetics
RNA Precursors / metabolism
RNA Stability
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism*
Ubiquitination

Substances

MicroRNAs
RNA Precursors
RNA, Long Noncoding