The effect of shock wave (SW) and beta-radiation (beta) on Lactuca sativa L. seeds was investigated. Exposure to SW at an amplitude of 200 and 600 MPa in various combinations with beta caused a lower survival rate and development of abnormal plants. At an amplitude of 600 MPa, when the SW + beta protocol was used, the maximum amount of abnormalities was seen after 220-240 hours of wetting and when the beta + SW protocol was used the maximum amount of abnormalities was seen after 80-100 hours of wetting. At an amplitude of 600 MPa, the most significant changes in the germination of seeds at different SW and beta combinations were observed. When seeds were first exposed to beta and then to SW, most significant changes were recorded suggesting synergism of the above factors. These observations can be considered as indirect evidence in support of the hypothesis that SW may also occur around the track of a heavy charged particle.