Emergence of Serratia marcescens isolates possessing carbapenem-hydrolysing β-lactamase KPC-2 from China

J Hosp Infect. 2016 Sep;94(1):65-7. doi: 10.1016/j.jhin.2016.04.006. Epub 2016 Apr 21.

Abstract

Eighty-three carbapenem-resistant Serratia marcescens isolates were recovered from Zhejiang Provincial People's Hospital, China. The minimum inhibitory concentrations of imipenem, meropenem, and ertapenem for all isolates were 2 to >128 μg/mL. Polymerase chain reaction indicated that 63 S. marcescens isolates produced Klebsiella pneumoniae carbapenemase (KPC)-2. Clone A (15 isolates) and clone B (41 isolates) were the two dominant clones and clone A strains were gradually replaced by clone B strains between 2011 and 2014. The results indicate that blaKPC-2-positive S. marcescens emerged in our hospital as the major mechanism of carbapenem resistance.

Keywords: Carbapenem; Carbapenemase; ERIC–PCR; KPC-2; Resistance; Serratia marcescens.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / metabolism*
  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / metabolism*
  • China / epidemiology
  • DNA, Bacterial / genetics
  • Ertapenem
  • Female
  • Genotype
  • Hospitals
  • Humans
  • Hydrolysis
  • Imipenem / metabolism
  • Imipenem / pharmacology
  • Male
  • Meropenem
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Typing
  • Polymerase Chain Reaction
  • Serratia Infections / epidemiology*
  • Serratia Infections / microbiology*
  • Serratia marcescens / classification
  • Serratia marcescens / enzymology*
  • Serratia marcescens / genetics
  • Serratia marcescens / isolation & purification
  • Thienamycins / metabolism
  • Thienamycins / pharmacology
  • Young Adult
  • beta-Lactamases / genetics*
  • beta-Lactams / metabolism
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • DNA, Bacterial
  • Thienamycins
  • beta-Lactams
  • Imipenem
  • beta-lactamase KPC-2
  • beta-Lactamases
  • Meropenem
  • Ertapenem