Abstract
Eighty-three carbapenem-resistant Serratia marcescens isolates were recovered from Zhejiang Provincial People's Hospital, China. The minimum inhibitory concentrations of imipenem, meropenem, and ertapenem for all isolates were 2 to >128 μg/mL. Polymerase chain reaction indicated that 63 S. marcescens isolates produced Klebsiella pneumoniae carbapenemase (KPC)-2. Clone A (15 isolates) and clone B (41 isolates) were the two dominant clones and clone A strains were gradually replaced by clone B strains between 2011 and 2014. The results indicate that blaKPC-2-positive S. marcescens emerged in our hospital as the major mechanism of carbapenem resistance.
Keywords:
Carbapenem; Carbapenemase; ERIC–PCR; KPC-2; Resistance; Serratia marcescens.
Copyright © 2016 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / metabolism*
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Anti-Bacterial Agents / pharmacology
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Carbapenems / metabolism*
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China / epidemiology
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DNA, Bacterial / genetics
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Ertapenem
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Female
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Genotype
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Hospitals
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Humans
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Hydrolysis
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Imipenem / metabolism
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Imipenem / pharmacology
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Male
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Meropenem
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Microbial Sensitivity Tests
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Middle Aged
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Molecular Typing
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Polymerase Chain Reaction
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Serratia Infections / epidemiology*
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Serratia Infections / microbiology*
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Serratia marcescens / classification
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Serratia marcescens / enzymology*
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Serratia marcescens / genetics
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Serratia marcescens / isolation & purification
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Thienamycins / metabolism
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Thienamycins / pharmacology
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Young Adult
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beta-Lactamases / genetics*
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beta-Lactams / metabolism
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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Thienamycins
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beta-Lactams
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Imipenem
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beta-lactamase KPC-2
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beta-Lactamases
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Meropenem
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Ertapenem