Advances of Phenoxazines: Synthesis, Reactivity and Their Medicinal Applications

Curr Med Chem. 2016;23(26):2972-2999. doi: 10.2174/0929867323666160510123023.

Abstract

Phenoxazines are an important class of heterocycles, which are emerging in the field of medicinal chemistry. They exhibit numerous biological activities, including antiviral, anticancer, anti-Alzheimer, antidiabetic, antioxidant, anti-inflammatory, antibiotic and many more. The present review focuses on the chemistry along with the medicinal applications of the phenoxazine moiety, in order to provide a greater insight for the development of future phenoxazine therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Agents / toxicity
  • Apoptosis / drug effects
  • Bacterial Proteins / metabolism
  • Mycobacterium / drug effects
  • Neoplasms / drug therapy
  • Oxazines / chemical synthesis
  • Oxazines / chemistry*
  • Oxazines / metabolism
  • Oxidoreductases / metabolism
  • Streptomyces / enzymology

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Bacterial Proteins
  • Oxazines
  • phenoxazine
  • Oxidoreductases
  • 2-aminophenol oxidase