Abstract
An efficient palladium-catalyzed α-alkenylation of pyridylmethyl ethers with vinyl bromides is presented. A Pd/NIXANTPHOS-based catalyst system enables a mild and chemoselective coupling between a variety of pyridylmethyl ethers and vinyl bromides in good to excellent yields. Under the mild conditions, β,γ-unsaturated products are obtained without isomerization or Heck byproducts observed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Catalysis
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Chemistry Techniques, Synthetic
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Ethers / chemical synthesis*
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Ethers / chemistry
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Hydrogen Bonding
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Palladium / chemistry*
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Vinyl Compounds / chemistry*
Substances
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Ethers
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Pyridines
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Vinyl Compounds
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Palladium
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vinyl bromide