Superfluorinated PEI Derivative Coupled with (99m) Tc for ASGPR Targeted (19) F MRI/SPECT/PA Tri-Modality Imaging

Zhide Guo; Mengna Gao; Manli Song; Yesen Li; Deliang Zhang; Duo Xu; Linyi You; Liangliang Wang; Rongqiang Zhuang; Xinhui Su; Ting Liu; Jin Du; Xianzhong Zhang

doi:10.1002/adma.201601064

Superfluorinated PEI Derivative Coupled with (99m) Tc for ASGPR Targeted (19) F MRI/SPECT/PA Tri-Modality Imaging

Adv Mater. 2016 Jul;28(28):5898-906. doi: 10.1002/adma.201601064. Epub 2016 May 9.

Authors

Zhide Guo^{1

2}, Mengna Gao¹, Manli Song¹, Yesen Li¹, Deliang Zhang¹, Duo Xu¹, Linyi You¹, Liangliang Wang³, Rongqiang Zhuang¹, Xinhui Su³, Ting Liu¹, Jin Du², Xianzhong Zhang¹

Affiliations

¹ Center for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, 361102, China.
² Department of Isotope, China Institute of Atomic Energy, Beijing, 102413, China.
³ Zhongshan Hospital Affiliated of Xiamen University, Xiamen, 361004, China.

PMID: 27159903
DOI: 10.1002/adma.201601064

Abstract

Fluorinated polyethylenimine derivative labeled with radionuclide (99m) Tc is developed as a (19) F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)-targeting ability. This multifunctional agent is safe and suitable for (19) F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.

Keywords: 19F magnetic resonance imaging; liver function; molecular imaging; photoacoustic imaging; single-photon-emission computed tomography.