A dual-site two-photon fluorescent probe for visualizing lysosomes and tracking lysosomal hydrogen sulfide with two different sets of fluorescence signals in the living cells and mouse liver tissues

Yong Liu; Fangfang Meng; Longwei He; Keyin Liu; Weiying Lin

doi:10.1039/c6cc02368a

A dual-site two-photon fluorescent probe for visualizing lysosomes and tracking lysosomal hydrogen sulfide with two different sets of fluorescence signals in the living cells and mouse liver tissues

Chem Commun (Camb). 2016 May 19;52(43):7016-9. doi: 10.1039/c6cc02368a.

Authors

Yong Liu¹, Fangfang Meng¹, Longwei He¹, Keyin Liu¹, Weiying Lin²

Affiliations

¹ Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Jinan, Shandong 250022, P. R. China. weiyinglin2013@163.com.
² Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Jinan, Shandong 250022, P. R. China. weiyinglin2013@163.com and State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China.

PMID: 27159054
DOI: 10.1039/c6cc02368a

Abstract

Herein, we have developed a novel dual-site two-photon fluorescent probe as the first paradigm of the probes, which can concurrently report lysosomes and lysosomal H2S with two different sets of fluorescence signals in the living cells and tissues.

MeSH terms

A549 Cells
Animals
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
Humans
Hydrogen Sulfide / chemistry*
Liver / chemistry
Liver / cytology*
Lysosomes / chemistry*
Mice
Molecular Imaging

Substances

Fluorescent Dyes
Hydrogen Sulfide