PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications

Mater Sci Eng C Mater Biol Appl. 2016 Aug 1:65:164-71. doi: 10.1016/j.msec.2016.03.104. Epub 2016 Apr 7.

Abstract

PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.

Keywords: Drug delivery; PAMAM dendrimers; Small molecule drugs; TiO(2) nanotubes.

MeSH terms

  • Cell Survival / drug effects
  • Curcumin / chemistry
  • Curcumin / metabolism
  • Curcumin / toxicity
  • Dendrimers / chemistry*
  • Drug Carriers / chemistry*
  • Drug Liberation
  • HeLa Cells
  • Humans
  • Methotrexate / chemistry
  • Methotrexate / metabolism
  • Methotrexate / toxicity
  • Microscopy, Electron, Transmission
  • Nanotubes / chemistry*
  • Pharmaceutical Preparations / chemistry*
  • Pharmaceutical Preparations / metabolism
  • Silybin
  • Silymarin / chemistry
  • Silymarin / metabolism
  • Silymarin / toxicity
  • Spectroscopy, Fourier Transform Infrared
  • Titanium / chemistry*

Substances

  • Dendrimers
  • Drug Carriers
  • PAMAM Starburst
  • Pharmaceutical Preparations
  • Silymarin
  • titanium dioxide
  • Silybin
  • Titanium
  • Curcumin
  • Methotrexate