The self-assembly of a camptothecin-lysine nanotube

Yuan Sun; Aileen Shieh; Se Hye Kim; Samantha King; Anne Kim; Hui-Lung Sun; Carlo M Croce; Jon R Parquette

doi:10.1016/j.bmcl.2016.04.056

The self-assembly of a camptothecin-lysine nanotube

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2834-2838. doi: 10.1016/j.bmcl.2016.04.056. Epub 2016 Apr 21.

Authors

Yuan Sun¹, Aileen Shieh¹, Se Hye Kim¹, Samantha King¹, Anne Kim¹, Hui-Lung Sun², Carlo M Croce², Jon R Parquette¹

Affiliations

¹ Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
² Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA.

PMID: 27156772
DOI: 10.1016/j.bmcl.2016.04.056

Abstract

A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against cancer cell lines A549, NCI-H460 and NCI-H23. The release of active camptothecin was highly dependent on conjugate concentration, temperature and pH of the solution.

Keywords: Cytotoxicity; Drug delivery; Nanoparticle; Nanotube; Self-assembly.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Camptothecin / chemistry
Camptothecin / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Hydrogen-Ion Concentration
Lysine / chemistry
Lysine / pharmacology*
Molecular Structure
Nanotubes / chemistry*
Particle Size
Structure-Activity Relationship
Temperature

Substances

Antineoplastic Agents
Lysine
Camptothecin