Flavonoid profile and antileukemic activity of Coreopsis lanceolata flowers

Antoni Pardede; Koharu Mashita; Masayuki Ninomiya; Kaori Tanaka; Mamoru Koketsu

doi:10.1016/j.bmcl.2016.04.069

Flavonoid profile and antileukemic activity of Coreopsis lanceolata flowers

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2784-2787. doi: 10.1016/j.bmcl.2016.04.069. Epub 2016 Apr 23.

Authors

Antoni Pardede¹, Koharu Mashita², Masayuki Ninomiya³, Kaori Tanaka⁴, Mamoru Koketsu⁵

Affiliations

¹ Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry Education, Islamic University of Kalimantan, Jl. Adhyaksa No. 2 Kayu Tangi, Banjarmasin 70123, Indonesia.
² Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
³ Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
⁴ Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan; United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
⁵ Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Materials Science and Technology, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Electronic address: koketsu@gifu-u.ac.jp.

PMID: 27155901
DOI: 10.1016/j.bmcl.2016.04.069

Abstract

Coreopsis lanceolata is a perennial plant belonging to the Asteraceae family. In this study, flavonoid profile and antileukemic potential of yellow flowers of the plant were investigated. The total flavonoid content in EtOAc fraction of the flower methanol extract was found to be 420mg/g and showed the inhibition of cell proliferation and possible induction of apoptosis in human leukemia HL-60 cells. Our phytochemical research led to the isolation of rare flavonoids including a flavanone, chalcones, and aurones; in particular, 4-methoxylanceoletin demonstrated the potent antiproliferative activity. Comparison with other Asteraceaeous flowers by UPLC-MS analysis indicated that the isolates are characteristic constituents of C. lanceolata.

Keywords: 4-Methoxylanceoletin; Antileukemic activity; Aurone; Chalcone; Coreopsis lanceolata.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Cell Proliferation / drug effects
Cell Survival / drug effects
Coreopsis / chemistry*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Flowers / chemistry*
HL-60 Cells
Humans
Molecular Structure
Structure-Activity Relationship

Substances

Antineoplastic Agents, Phytogenic
Flavonoids