Isocoumarins, miraculous natural products blessed with diverse pharmacological activities

Eur J Med Chem. 2016 Jun 30:116:290-317. doi: 10.1016/j.ejmech.2016.03.025. Epub 2016 Mar 17.

Abstract

Isocoumarins are lactonic natural products abundant in microbes and higher plants. These are considered an amazing scaffold consecrated with more or less all types of pharmacological applications. This review is complementary to the earlier reviews and aims to focus the overlooked aspects of their fascinating chemistry with special emphasis on their classification and diverse biological activities with some SAR conclusions. The most recent available literature on the structural diversity and biological activity of these natural products has been reviewed.

Keywords: Biological activities; Classification; Isocoumarins; Natural products.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Humans
  • Isocoumarins / chemistry
  • Isocoumarins / pharmacology*

Substances

  • Biological Products
  • Isocoumarins