Targeted Treatment in Childhood Epilepsy Syndromes

Katharina Vezyroglou; J Helen Cross

doi:10.1007/s11940-016-0407-4

Targeted Treatment in Childhood Epilepsy Syndromes

Curr Treat Options Neurol. 2016 Jun;18(6):29. doi: 10.1007/s11940-016-0407-4.

Authors

Katharina Vezyroglou¹, J Helen Cross^{2

3}

Affiliations

¹ Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK.
² Clinical Neurosciences, 30 Guilford St, London, WC1N 1EH, UK. h.cross@ucl.ac.uk.
³ Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK. h.cross@ucl.ac.uk.

Abstract

The mainstay of treatment of epilepsy has been antiepileptic drugs; however, despite the emergence of new agents, a consistent proportion remain drug-resistant. Newer AEDs show promise. However, as it becomes clear that the epilepsies are a group of diseases rather than a single disorder the prospect of targeted treatment in some may become a reality.

Keywords: Antiepileptic drugs (AED); Cannabidiol (CBD); Childhood epilepsies; Epileptic encephalopathy; Ketogenic diet (KD); Next generation sequencing (NGS); Targeted therapy.

Publication types

Review